Bills vs. Titans score: Live updates, TV, live streaming, odds for ‘Monday Night Football’ opener

The Buffalo Bills get their chance for some Monday night revenge, as Josh Allen and Stefon Diggs host Derrick Henry and the Tennessee Titans. These two teams faced off under the Monday night lights of Nashville last season in Week 6, as the Titans escaped with a 34-31 victory thanks to a Jeffery Simmons goal-line stand, and 143 rushing yards and three touchdowns from Henry. After an offseason of changes, however, things could go differently this time around.

Both teams have injury issues entering this matchup. The Bills will be without defensive linemen Ed Oliver and Tim Settle, as well as starting wideout Gabe Davis. For the Titans, they will be without their No. 1 cornerback Kristian Fulton, and running back Dontrell Hilliard — who caught two touchdowns in Tennessee’s Week 1 loss to the New York Giants.  

Settle in for this primetime battle between two solid squads. The Bills and Titans are two of just four teams to earn playoff berths in each of the past three years. Follow along in the live blog below, as we break down this AFC heavyweight matchup as it happens.  

All NFL odds are via Caesars Sportsbook

How to watch

Date: Monday, Sept. 19 | Time: 7:15 p.m. ET
Location: Highmark Stadium (Orchard Park, New York)
 ESPN | Stream: fuboTV (click here)
Follow: CBS Sports App
Odds: Bills -10, O/U 47.5

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