Monday Night Football odds, line: 49ers vs. Cardinals prediction, Mexico City NFL picks by expert who’s 13-3

In 2005, the Arizona Cardinals defeated the San Francisco 49ers in the first regular-season NFL game ever played outside the United States. On Monday, the same two teams will meet in the same location for the fourth NFL in Mexico City game. Estadio Azteca will showcase Monday Night Football, the final contest of Week 11. The 49ers are 5-4 this season, while the Cardinals are 4-6 after a 2-4 stretch over the last six games.

Kickoff is at 8:15 p.m. ET in Mexico. Caesars Sportsbook lists the 49ers as 10-point favorites, while the over/under, or total number of points Vegas thinks will be scored, is 42.5 in the latest 49ers vs. Cardinals odds. Before you make any Cardinals vs. 49ers picks and NFL predictions, you need to see what SportsLine’s top 49ers expert, Micah Roberts, has to say.

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos’ book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. He’s also on a 13-3 roll on his last 16 picks involving the 49ers, making him the most well-qualified expert to pick Monday Night Football.

Now, Roberts has set his sights on 49ers vs. Cardinals and just locked in his picks and MNF predictions. You can head to SportsLine now to see his picks. Now, here are several NFL odds and betting lines for 49ers vs. Cardinals:

  • 49ers vs. Cardinals spread: 49ers -10
  • 49ers vs. Cardinals over/under: 42.5 points 
  • 49ers vs. Cardinals money line: 49ers -480, Cardinals +360
  • SF: 49ers are 4-5 against the spread this season 
  • AZ: Cardinals are 5-5 against the spread this season 
  • 49ers vs. Cardinals picks: See picks here

Featured Game | Arizona Cardinals vs. San Francisco 49ers

Why the 49ers can cover

San Francisco has one of the best defenses in the league, headlined by a game-changer in Nick Bosa. He is a Pro Bowl defensive end who led the NFL in tackles for loss in 2021. Bosa has 34 sacks in 43 career games and leads the league with 24 quarterback hits this season. Bosa is also in the top three of the NFL with 9.5 sacks, 45 pressures, and 11 tackles for loss.

As a team, San Francisco ranks in the top five with 29 sacks and is No. 1 in total yards allowed (280.6 per game), first downs allowed, rushing yards allowed (82.7 per game), and yards allowed per rush attempt (3.4). The 49ers are also in the top five in points allowed per game (18.1), points allowed per drive (1.60), and yards allowed per drive (27.2). San Francisco is strong against the pass, holding opponents to 197.9 yards per through the air, and the 49ers have allowed only nine passing touchdowns and 5.6 net yards per pass attempt. See which team covers here.

Why the Cardinals can cover

Arizona is capable of explosions on offense. The Cardinals are above the NFL average in generating 23.0 points per game and have 206 first downs this season. Arizona takes care of the ball with only nine turnovers in 10 games and is effective near the goal line, posting a 60.0% red zone efficiency.

San Francisco is below-average in turnover creation on defense with only 10 takeaways and gives up a touchdown on 61.9% of red zone trips. On the other side, Arizona also creates havoc with 14 turnovers, a top-10 mark in the NFL, and the Cardinals are suited to slow San Francisco’s run-heavy offense with 4.4 yards allowed per carry and 110.5 rushing yards allowed per game. San Francisco also has 13 turnovers in nine games on offense, including seven lost fumbles. See which team covers here.

How to make 49ers vs. Cardinals picks

Roberts has analyzed this matchup and while we can tell you he’s leaning Over on the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.

Who wins Cardinals vs. 49ers on Monday Night Football in Mexico City? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Cardinals vs. 49ers spread to back, all from the expert who’s 13-3 on Niners picks, and find out.

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