Vivid Microscopy’s technology detects stages of cardiac microvascular disease using an animal-based model as demonstrated in a University of Louisville study

Vivid Microscopy’s high content screening probes now widely available through biotech supplier Kerafast Inc.

WAUWATOSA, Wis., Oct. 26, 2022 /PRNewswire/ — Vivid Microscopy, an emerging biotech company in the United States, today announced the successful use of its high content screening probe, SEMKUR-IM, in a study conducted by the University of Louisville on coronary microvascular disease (CMD) in post-menopausal women. 

A disease impacting over 3 million women yearly, microvascular dysfunction often presents with chest pain and shortness of breath, which can lead to heart failure. The current method of detection is through an angiogram or a specialized form of ultrasound. Early detection of the microvascular dysregulation signal is critical—if left undetected, it can lead to heart failure or a massive heart attack.

In experiments by the University of Louisville published in Antioxidant & Redox Signaling, scientists looked at four different conditions of cells and used various indicators to assess each state. Vivid’s probe was unique in that it could detect all stages of CMD (with minimal standard deviation) impacting blood supply to the heart. Using fluorescent technology, the SEMKUR-IM tool was able to differentiate the severity of the condition from initial stages to the most extreme, as well as assess the effectiveness of drugs targeted to treat the condition.

“Vivid Microscopy’s product was the only technology we were able to find that can detect glutathione in living cells. SEMKUR-IM was the only product that could be made up in our physiologic salt solution and then infused. Most other fluorescent products required cell or tissue fixation first, which wouldn’t allow us to study in real time how glutathione levels change during response to stimuli such as intraluminal fluid flow or drug agonists,” stated Dr. Evan Tracy of the University of Louisville, working under the direction of Dr. Amanda LeBlanc.

The University of Louisville’s study has demonstrated how Vivid’s probe can be used to ascertain the effectiveness of new cardiovascular treatments. According to Jayson Kurfis, CEO of Vivid Microscopy, “These methods provide an opportunity to greatly improve a patient’s quality of life while decreasing rates of mortality, thereby making SEMKUR-IM an invaluable tool for the development of drugs and interventions that address heart disease.”

Scientists, researchers and the medical community can now purchase these pre-clinical evaluation tools at, an online platform providing researchers access to unique lab-made bioresearch materials.


At Vivid Microscopy, our mission is to improve the speed and accuracy of pre-clinical evaluation tools that provide researchers and scientists with quantitative results. Using fluorescent technology to detect biomarkers associated with cellular injury, Vivid Microscopy has manufactured SEMKUR-IM, a quantitative test to evaluate cellular damage. We are dedicated to providing scientists and researchers with predictive technology that can be used to facilitate disease diagnosis and drug development. Vivid Microscopy is based in Wauwatosa, WI and manufactures its products in the USA.

SOURCE Vivid Microscopy

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