Week 1 NFL picks, odds, 2022 best bets from advanced model: This 5-way football parlay pays out 25-1

The Nathaniel Hackett era begins in Denver when the Denver Broncos open the season against the Seattle Seahawks on Monday Night Football to close out the Week 1 NFL schedule. The 42-year-old Hackett has 19 years of experience as a college and NFL assistant, but the Broncos job is his first as a head coach. Denver is favored by 6.5 points in the latest NFL odds from Caesars Sportsbook, but which NFL bets should you make? The game is one of 16 on a loaded Week 1 NFL schedule. Other key NFL matchups include the reigning Super Bowl champion Rams hosting the Bills in the 2022 NFL Kickoff Game, and the Cowboys and Buccaneers colliding in a rematch of last season’s thrilling opener. Before you make any Week 1 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 1. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 1 NFL picks at SportsLine. 

Top Week 1 NFL picks

After simulating every game 10,000 times, the model is high on the Indianapolis Colts to cover as eight-point road favorites against the Houston Texans. Indianapolis enters 2022 off a 9-8 campaign in which the team lost back-to-back games to end the season and barely missed the playoffs. Meanwhile Houston, playing without quarterback Deshaun Watson, went 4-13 in a rebuilding year.

The Colts face a Texans offense that was punch-less last season. Houston ranked last in the league in total offense (278.1 yards a game) and rushing offense (83.6) and third-to-last in scoring offense (16.5). In the two matchups between the teams last season, the Texans managed a combined three points. See which other NFL parlay picks to make here.

How to make Week 1 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including an underdog that wins outright. You can only see the model’s NFL Week 1 best bets and parlay at SportsLine. 

What are the model’s top Week 1 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 138-97 run on its top-rated picks, and find out.

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